Ano de Publicação: 2014
AUTORIA
Rog erio Gondak, Thais Mauad,1 Luciana Schultz,2 Fernando Soares,2 Luiz P Kowalski3 &
Pablo A Vargas4
Department of Pathology, Federal University of Santa Catarina, Florian opolis, Brazil, 1Department of Pathology, Sao
Paulo University Medical School, S~ao Paulo, Brazil, 2Department of Pathology, AC Camargo Hospital, S~ao Paulo,
Brazil, 3Department of Head and Neck, AC Camargo Hospital, S~ao Paulo, Brazil, and 4Department of Oral Diagnosis,
Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
RESUMO
Aims: The purpose of this study was to quantify and
compare the density of dendritic cells (DCs) in cervical
lymph nodes (LNs) and palatine tonsils (PTs) of AIDS
and non-AIDS patients.
Methods and results: Factor XIIIa, CD1a and CD83
antibodies were used to identify migratory DCs by
immunohistochemistry in LNs and PTs of 32 AIDS
patients and 21 HIV-negative control patients. Quantification
was performed by the positive pixel count
analytical method. AIDS patients presented a lower
density of factor XIIIa+ cells (P < 0.001), CD1a+ cells
(P < 0.05) and CD83+ cells (P < 0.001) in cervical
LNs and PTs compared to the non-AIDS control
group.
Conclusion: Overall depletion of DCs in lymphoid tissues
of AIDS patients may be predictive of the
immune system’s loss of disease control.