Ano de Publicação: 2018
AUTORIA
Edson S. Bezerra a,b, c, Oswaldo Pio Andrighetto C, Marcus V.S. Costa a,
Leandro O. Chiarelli a, b, Willian Moleiro a
* Faculdade de Medicina São Leopoldo Mandic – Campinas, Rua João Lino, 914, CEP: 13450-033, Santa Barbara d’Oeste, SP, Brazil
• Hospital da Santa Casa de Santa Bárbara D’Oeste, Rua João Lino, 914, CEP: 13450-033, Santa Barbara d’Oeste, SP, Brazil
* Hospital Municipal Dr. Mário Gatti, Av. Prefeito Faria Lima, 340, CEP: 13036-902, Campinas, SP, Brazil
• Instituto de Anatomia Patológica, Rua General Câmara, 1136, 5° andar, CEP: 13450-029, Santa Barbara d’Oeste, SP, Brazi
RESUMO
Solitary fibrous tumors (STF) are uncommon neoplasms that typically arise from the pleura and have unpredictable behavior.
Extrapleural SFTs are rare in the genitourinary tract, where they more often involve the kidney. Definition between primary or metastatic SPT is critical for patient management, impacting prognosis and treatment. SFTs share many similarities to heman-giopericytoma (HPC), but recent molecular improvements place most HPC as cellular variants of SFT. We describe the case of bilateral renal masses in a young male, exemplifying why such a shift in terminology is important, especially when molecular knowledge can be translated into acessible diagnostic tools.
In 1870 Wagner described a fibrous or reticular tumor (“retikuliert tuberkel”) with malignant features involving the pleura. The term “solitary” was proposed later to differentiate from mesothelioma. SFT and HPC have since been separate entities by the WHO Classifications of several organs. However, over time, the vascular pattern characteristic of HPCs was found in 15% of all soft-tissue tumors, suggesting that this feature represents a histologic pattern instead of a clinicopathologic entity. Furthermore, recent research showed that these lesions share the chromosomal fusion’ NAB-STAT6, leading the following WHO editions to incorporate most HPC as part of the spectrum of SFT.